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Lupe [1]

Dr. Hendrik F. T. Klare


Institut für Chemie
Sekr. C3
Straße des 17. Juni 115
10623 Berlin, Germany


fon: +49 30 314 29909
fax: +49 30 314 75804

email: hendrik.klare(at)tu-berlin.de [2]

Research Gate [3]

ORCID
[4]

Academic Career
  • Senior Scientist/Lecturer with Professor Martin Oestreich at the Technische Universität Berlin, Germany (January 2013 present)
  • Postdoc with Professor Brian M. Stoltz at the California Institute of Technology, Pasadena, USA (December 2011 December 2012)
    "Oxidative Coupling of Oxindoles with Nucleophiles"
  • Research Stay with Professor Gerhard Erker at the Westfälische Wilhelms-Universität Münster, Germany (September 2011 November 2011)
    "SiH Bond Activation with Frustrated Lewis Pairs"
  • Ph.D. with Professor Martin Oestreich at the Westfälische Wilhelms-Universität Münster, Germany (April 2007 May 2011)
    "Generation of Stabilized Silylium Ions for Catalysis"
  • Research Stay with Professor Kazuyuki Tatsumi at Nagoya University, Japan (September 2009 March 2010)
    "Cooperative SiH Bond Activation with Transition Metal Thiolate Complexes"
  • Diploma with Professor Martin Oestreich at the Westfälische Wilhelms-Universität Münster, Germany (October 2006 March 2007)
    "Rhodium-Catalyzed Dehydrogenative SiO Coupling: Chiral Recognition with Silicon-Stereogenic Silanes"
  • Studies in Chemistry at the Westfälische Wilhelms-Universität Münster, Germany (October 2001 March 2007)
Scholarships
  • Postdoctoral Research Fellowship of the German Academic Exchange Service (DAAD) (December 2011 November 2012)
  • Predoctoral Fellowship of the International Research Training Group (IRTG) Münster–Nagoya "Complex Functional Systems in Chemistry: Design, Development and Applications", GRK 1143 of the Deutsche Forschungsgemeinschaft (DFG) (April 2007 March 2010)

Publications

Lupe [5]

44.
T. He, H. F. T. Klare,* and M. Oestreich*,
Silylium-Ion Regeneration by Protodesilylation Enables Friedel–Crafts Alkylation with Less Isomerization and No Defunctionalization,
ACS Catal. 2021, 11, 12186-12193 [6]. (Abstract [7])

Lupe [8]

43.
H. F. T. Klare* and M. Oestreich*,
The Power of the Proton: From Superacidic Media to Superelectrophile Catalysis (Perspective),
J. Am. Chem. Soc. 2021, 143, 15490-15507 [9]. (Abstract [10])

Lupe [11]

42.
H. F. T. Klare,* L. Albers, L. Süsse, S. Keess, T. Müller,* and M. Oestreich*,
Silylium Ions: From Elusive Reactive Intermediates to Potent Catalysts (Review),
Chem. Rev. 2021, 121, 5889-5985 [12]. (Abstract [13])

Lupe [14]

41.
T. He, G. Wang, P.-W. Long, S. Kemper, E. Irran, H. F. T. Klare,* and M. Oestreich*,
Intramolecular FriedelCrafts alkylation with a silylium-ion-activated cyclopropyl group: formation of tricyclic ring systems from benzyl-substituted vinylcyclopropanes and hydrosilanes,
Chem. Sci. 2021, 12, 569-575 [15]. (Abstract)
Selected for the 2020 Chemical Science HOT Article Collection [16].
(open access)
Highlighted in SYNFACTS 2021, 17, 623 [17].

Lupe [18]

40.
M. Oberling, E. Irran, Y. Ohki,* H. F. T. Klare,* and M. Oestreich*,
Cationic Ru–Se Complexes for Cooperative Si–H Bond Activation,
Organometallics 2020, 39, 4747-4753 [19]. (Abstract [20])

Lupe [21]

39.
T. He, G. Wang, V. Bonetti, H. F. T. Klare, and M. Oestreich*,
Silylium-Ion-Promoted (5+1) Cycloaddition of Aryl-Substituted Vinylcyclopropanes and Hydrosilanes Involving Aryl Migration,
Angew. Chem. 2020, 132, 12284-12289;
Angew. Chem. Int. Ed. 2020, 59, 12186-12191 [22]. (Abstract [23])
(open access)

Lupe [24]

38.
Q. Wu, A. Roy, G. Wang, E. Irran, H. F. T. Klare, and M. Oestreich*,
Synthesis of a Counteranion-Stabilized Bis(silylium) Ion,
Angew. Chem. 2020, 132, 10609-10613;
Angew. Chem. Int. Ed. 2020, 59, 10523-10526 [25]. (Abstract [26])
Highlighted as a "Very Important Paper (VIP)" by Angewandte Chemie.
(open access)

Lupe [27]

37.
H. Yehia, S. Westarp, V. Röhrs, F. Kaspar, R. T. Giessmann, H. F. T. Klare, K. Paulick, P. Neubauer, J. Kurreck, and A. Wagner*,
Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations,
Molecules 2020, 25, 934 [28]. (Abstract [29])
(open access)

Lupe [30]

36.
A. Roy, V. Bonetti, G. Wang, Q. Wu, H. F. T. Klare, and M. Oestreich*,
Silylium-Ion-Promoted Ring-Opening Hydrosilylation and Disilylation of Unactivated Cyclopropanes,
Org. Lett. 2020, 22, 1213-1216 [31]. (Abstract [32])

Lupe [33]

35.
J. C. L. Walker, H. F. T. Klare, and M. Oestreich*,
Cationic silicon Lewis acids in catalysis (Perspective),
Nat. Rev. Chem. 2020, 4, 54-62 [34]. (Abstract [35])
Commentary: Nat. Rev. Chem. 2020, 4, 4-5 [36].

Lupe [37]

34.
J. Fuchs, E. Irran, P. Hrobárik,* H. F. T. Klare,* and M. Oestreich*,
SiH Bond Activation with Bullock's Cationic Tungsten(II) Catalyst: CO as Cooperating Ligand,
J. Am. Chem. Soc. 2019, 141, 18845-18850 [38]. (Abstract [39])

Lupe [40]

33.
Q. Wu, A. Roy, E. Irran, Z.-W. Qu,* S. Grimme, H. F. T. Klare, and M. Oestreich*,
Catalytic Difunctionalization of Unactivated Alkenes with Unreactive Hexamethyldisilane through Regeneration of Silylium Ions,
Angew. Chem. 2019, 131, 17468-17472;
Angew. Chem. Int. Ed. 2019, 58, 17307-17311 [41]. (Abstract [42])
Highlighted as a "Very Important Paper (VIP)" by Angewandte Chemie.
(open access)
Highlighted in SYNFACTS 2019, 15, 1427 [43].

Lupe [44]

32.
Q. Wu, E. Irran, R. Müller, M. Kaupp, H. F. T. Klare,* and M. Oestreich*,
Characterization of hydrogen-substituted silylium ions in the condensed phase,
Science 2019, 365, 168-172 [45]. (Abstract [46])
Highlighted in Nachr. Chem. 2019, 67, 47 [47].
Highlighted in Nachr. Chem. 2020, 68, 50-64 [48].

Lupe [49]

31.
A. Merk, H. Großekappenberg, M. Schmidtmann, M.-P. Luecke, C. Lorent, M. Driess, M. Oestreich, H. F. T. Klare,* and T. Müller*,
Single-Electron Transfer Reactions in Frustrated and Conventional Silylium Ion/Phosphane Lewis Pairs,
Angew. Chem. 2018, 130, 15487-15492;
Angew. Chem. Int. Ed. 2018, 57, 15267-15271 [50]. (Abstract [51])
Highlighted in Nat. Rev. Chem. 2018, 2, 255 [52].
Highlighted in Nachr. Chem. 2020, 68, 50-64 [53].

Lupe [54]

30.
S. Kamel, M. Weiß, H. F. T. Klare, I. A. Mikhailopulo, P. Neubauer, and A. Wagner*,
Chemo-enzymatic synthesis of α-D-pentofuranose-1-phosphates using thermostable pyrimidine nucleoside phosphorylases,
Mol. Catal. 2018, 458, 52-59 [55]. (Abstract [56])

Lupe [57]

29.
Q. Wu, Z.-W. Qu,* L. Omann, E. Irran, H. F. T. Klare, and M. Oestreich*,
Cleavage of Unactivated Si‒C(sp3) Bonds with Reed's Carborane Acids: Formation of Known and Unknown Silylium Ions,
Angew. Chem. 2018, 130, 9317-9320;
Angew. Chem. Int. Ed. 2018, 57, 9176-9179 [58]. (Abstract [59])
Highlighted in Nachr. Chem. 2018, 66, 942 [60].

Lupe [61]

28.
L. Omann, B. Pudasaini, E. Irran, H. F. T. Klare, M.-H. Baik,* and M. Oestreich*,
Thermodynamic versus kinetic control in substituent redistribution reactions of silylium ions steered by the counteranion,
Chem. Sci. 2018, 9, 5600-5607 [62]. (Abstract)
Selected for the 2018 Chemical Science HOT Article Collection [63].
(open access)

Lupe [64]

27.
L. Omann, Z.-W. Qu, E. Irran, H. F. T. Klare,* S. Grimme,* and M. Oestreich*,
Electrophilic Formylation of Arenes by Silylium Ion Mediated Activation of Carbon Monoxide,
Angew. Chem. 2018, 130, 8433-8437;
Angew. Chem. Int. Ed. 2018, 57, 8301-8305 [65]. (Abstract [66])

Lupe [67]

26.
J. Fuchs, H. F. T. Klare, and M. Oestreich*,
Two-Silicon Cycle for Carbonyl Hydrosilylation with Nikonov’s Cationic Ruthenium(II) Catalyst,
ACS Catal. 2017, 7, 8338-8342 [68]. (Abstract [69])

Lupe [70]

25.
H. F. T. Klare*,
Catalytic C–H Arylation of Unactivated C–H Bonds by Silylium Ion-Promoted C(sp2)–F Bond Activation (Perspective),
ACS Catal. 2017, 7, 6999-7002 [71]. (Abstract [72])

Lupe [73]

24.
L. Omann, C. D. F. Königs, H. F. T. Klare,* and M. Oestreich*,
Cooperative Catalysis at MetalSulfur Bonds (Account),
Acc. Chem. Res. 2017, 50, 1258-1269 [74]. (Abstract [75])

Lupe [76]

23.
W.-B. Liu, D. P. Schuman, Y.-F. Yang, A. A. Toutov, Y. Liang, H. F. T. Klare, N. Nesnas, M. Oestreich, D. G. Blackmond, S. C. Virgil, S. Banerjee, R. N. Zare, R. H. Grubbs, K. N. Houk,* and B. M. Stoltz*,
Potassium tert-Butoxide-Catalyzed Dehydrogenative C–H Silylation of Heteroaromatics: A Combined Experimental and Computational Mechanistic Study,
J. Am. Chem. Soc. 2017, 139, 6867-6879 [77]. (Abstract [78])

Lupe [79]

22.
H. F. T. Klare, A. F. G. Goldberg, D. C. Duquette, and B. M. Stoltz*,
Oxidative Fragmentations and Skeletal Rearrangements of Oxindole Derivatives,
Org. Lett. 2017, 19, 988-991 [80]. (Abstract [81])

Lupe [82]

21.
Q. Yin, H. F. T. Klare,* and M. Oestreich*,
Catalytic Friedel–Crafts C–H Borylation of Electron-Rich Arenes: Dramatic Rate Acceleration by Added Alkenes,
Angew. Chem. 2017, 129, 3766-3771;
Angew. Chem. Int. Ed. 2017, 56, 3712-3717 [83]. (Abstract [84])
Highlighted in SYNFACTS 2017, 13, 529 [85].

Lupe [86]

20.
H. F. T. Klare and M. Oestreich*,
Teaching nature the unnatural (Perspective),
Science 2016, 354, 970 [87]. (Abstract [88])

Lupe [89]

19.
Q. Yin, S. Kemper, H. F. T. Klare,* and M. Oestreich*,
Boron Lewis Acid-Catalyzed Hydroboration of Alkenes with Pinacolborane: BArF3 Does What B(C6F5)3 Cannot Do!,
Chem. Eur. J. 2016, 22, 13840-13844 [90]. (Abstract [91])

Lupe [92]

18.
Q.-A. Chen, H. F. T. Klare, and M. Oestreich*,
Brønsted Acid-Promoted Formation of Stabilized Silylium Ions for Catalytic Friedel–Crafts C–H Silylation,
J. Am. Chem. Soc. 2016, 138, 7868-7871 [93]. (Abstract [94])
ACS AuthorChoice (open access)

Lupe [95]

17.
R. K. Schmidt, H. F. T. Klare, R. Fröhlich, and M. Oestreich*,
Planar Chiral, Ferrocene-Stabilized Silicon Cations,
Chem. Eur. J. 2016, 22, 5376-5383 [96]. (Abstract [97])

Lupe [98]

16.
Q. Yin, H. F. T. Klare, and M. Oestreich*,
FriedelCrafts-Type Intermolecular CH Silylation of Electron-Rich Arenes Initiated by Base-Metal Salts,
Angew. Chem. 2016, 128, 3256-3260;
Angew. Chem. Int. Ed. 2016, 55, 3204-3207 [99]. (Abstract [100])

Lupe [101]

15.
T. Stahl, P. Hrobárik,* C. D. F. Königs, Y. Ohki, K. Tatsumi, S. Kemper, M. Kaupp, H. F. T. Klare,* and M. Oestreich*,
Mechanism of the cooperative SiH bond activation at RuS bonds,
Chem. Sci. 2015, 6, 4324-4334 [102]. (Abstract)
(open access)

Lupe [103]

14.
V. H. G. Rohde, P. Pommerening, H. F. T. Klare, and M. Oestreich*,
Intramolecularly Sulfur-Stabilized Silicon Cations as Lewis Acid Catalysts,
Organometallics 2014, 33, 3618-3628 [104]. (Abstract [105])

Lupe [106]

13.
T. T. Metsänen, P. Hrobárik,* H. F. T. Klare, M. Kaupp, and M. Oestreich*,
Insight into the Mechanism of Carbonyl Hydrosilylation Catalyzed by Brookhart's Cationic Iridium(III) Pincer Complex,
J. Am. Chem. Soc. 2014, 136, 6912-6915 [107]. (Abstract [108])
Highlighted in ChemCatChem 2014, 6, 2486-2489 [109].

Lupe [110]

12.
J. Hermeke, H. F. T. Klare, and M. Oestreich*,
Direct Catalytic Access to N-Silylated Enamines from Enolizable Imines and Hydrosilanes by Base-Free Dehydrogenative Si–N Coupling
(ISOS XVII Conference Issue New Frontiers and Challenges in Silicon Chemistry [111]),
Chem. Eur. J. 2014, 20, 9250-9254 [112]. (Abstract [113])

Lupe [114]

11.
C. D. F. Königs, H. F. T. Klare, and M. Oestreich*,
Catalytic 1,4-Selective Hydrosilylation of Pyridines and Benzannulated Congeners,
Angew. Chem. 2013, 125, 10260-10263;
Angew. Chem. Int. Ed. 2013, 52, 10076-10079 [115]. (Abstract [116])
Selected as a "Hot Paper" by Angewandte Chemie.

Lupe [117]

10.
T. Stahl, H. F. T. Klare,* and M. Oestreich*,
Main-Group Lewis Acids for C–F Bond Activation (Perspective),
ACS Catal. 2013, 3, 1578-1587 [118]. (Abstract [119])
Featured on the Cover of ACS Catalysis [120].

Lupe [121]

9.
C. D. F. Königs, M. F. Müller, N. Aiguabella, H. F. T. Klare, and M. Oestreich*,
Catalytic dehydrogenative SiN coupling of pyrroles, indoles, carbazoles as well as anilines with hydrosilanes without added base,
Chem. Commun. 2013, 49, 1506-1508 [122]. (Abstract [123])

Lupe [124]

8.
T. Stahl, H. F. T. Klare, and M. Oestreich*,
C(sp3)F Bond Activation of CF3-Substituted Anilines with Catalytically Generated Silicon Cations: Spectroscopic Evidence for a Hydride-Bridged RuS Dimer in the Catalytic Cycle,
J. Am. Chem. Soc. 2013, 135, 1248-1251 [125]. (Abstract [126])

Lupe [127]

7.
W. Nie, H. F. T. Klare, M. Oestreich, R. Fröhlich, G. Kehr, and G. Erker*,
Reversible Heterolytic SiH Bond Activation by an Intramolecular Frustrated Lewis Pair
(Special Issue dedicated to Professor Heribert Offermanns),
Z. Naturforsch. 2012, 67b, 987-994 [128]. (Abstract [129])

Lupe [130]

6.
C. D. F. Königs, H. F. T. Klare, Y. Ohki,* K. Tatsumi,* and M. Oestreich*,
Base-Free Dehydrogenative Coupling of Enolizable Carbonyl Compounds with Silanes,
Org. Lett. 2012, 14, 2842-2845 [131]. (Abstract [132])
Included into Organic Chemistry Highlights under www.organic-chemistry.org [133].

Lupe [134]

5.
H. F. T. Klare, M. Oestreich,* J.-i. Ito, H. Nishiyama, Y. Ohki,* and K. Tatsumi*,
Cooperative Catalytic Activation of SiH Bonds by a Polar RuS Bond: Regioselective Low-Temperature CH Silylation of Indoles under Neutral Conditions by a FriedelCrafts Mechanism,
J. Am. Chem. Soc. 2011, 133, 3312-3315 [135]. (Abstract [136])

Lupe [137]

4.
H. F. T. Klare and M. Oestreich*,
Silylium ions in catalysis (Perspective),
(Special Issue "New Horizon of Organosilicon Chemistry"),
Dalton Trans. 2010, 39, 9176-9184 [138]. (Abstract [139])

Lupe [140]

3.
H. F. T. Klare, K. Bergander, and M. Oestreich*,
Taming the Silylium Ion for Low-Temperature DielsAlder Reactions,
Angew. Chem. 2009, 121, 9241-9243;
Angew. Chem. Int. Ed. 2009, 48, 9077-9079 [141]. (Abstract [142])
Highlighted in Nachr. Chem. 2010, 58, 7 [143].
Highlighted in Angew. Chem. Int. Ed. 2012, 51, 4526-4528 [144].

Lupe [145]

2.
H. F. T. Klare and M. Oestreich*,
Asymmetric Ring-Closing Metathesis with a Twist (Highlight),
Angew. Chem. 2009, 121, 2119-2123;
Angew. Chem. Int. Ed. 2009, 48, 2085-2089 [146]. (Abstract [147])

Lupe [148]

1.
H. F. T. Klare and M. Oestreich*,
Chiral Recognition with Silicon-Stereogenic Silanes: Remarkable Selectivity Factors in the Kinetic Resolution of Donor-Functionalized Alcohols,
Angew. Chem. 2007, 119, 9496-9499;
Angew. Chem. Int. Ed. 2007, 46, 9335-9338 [149]. (Abstract [150])

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